Hormonal Control of Adrenocortical Cell Proliferation
نویسندگان
چکیده
منابع مشابه
Hormonal control of adrenocortical cell proliferation. Desensitization to ACTH and interaction between ACTH and fibroblast growth factor in bovine adrenocortical cell cultures.
A primary bovine adrenocortical cell culture system responsive to physiological concentrations of ACTH has been established. When added to cultures, ACTH inhibited DNA synthesis and cell division over the same concentration range required for stimulation of fluorogenic steroid production (0.01-10 nM). With chronic exposure to ACTH, cells became desensitized to the growth inhibitory effects of A...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1977
ISSN: 0021-9738
DOI: 10.1172/jci108782